IL-6-mediated activation of STAT3M-NM-1 prevents trauma/hemorrhagic shock-induced liver inflammation

ABSTRACT: We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS and the effect of IL-6 on this model with and without pharmacologic blockade of Stat3-mediated IL-6 and identified distinct members of the inflammasome de-regulated during T/HS that normalized with IL-6 administration during resuscitation. Adult male rats were subjected to either sham procedure, a trauma plus hemorrhagic shock (T/HS) procedure, T/HS with IL-6 versus PBS during resuscitation, or pretreatment with pharmacologic blockade of Stat3-mediated IL6 via GQ-ODN and after procedural compl

ORGANISM(S): Rattus norvegicus

SUBMITTER: Stephen Thacker 

PROVIDER: E-GEOD-27978 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress