MiRNA expression profiles from adult mouse frontal cortex and hippocampus

ABSTRACT: MicroRNAs (miRNAs) are small regulatory molecules that cause post-transcriptional gene silencing. Although some miRNAs are known to have region-specific expression patterns in the adult brain, the functional consequences of the region-specificity to the gene regulatory networks of the brain nuclei are not clear. Therefore, we studied miRNA expression patterns by miRNA-seq in two brain regions, frontal cortex (FCx) and hippocampus (HP), which have separate biological functions. We identified 354 miRNA from FCx and 408 from HP. Several miRNA families and clusters were differentially expressed between FCx and HP, including the miR-8 family, miR-182|miR-96|miR-183 cluster, and miR-212|miR-312 cluster overexpressed in FCx and miR-34 family overexpressed in HP. To visualize the clusters, we deve

ORGANISM(S): Mus musculus

SUBMITTER: Iiris Hovatta 

PROVIDER: E-GEOD-27979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress