PDE-4 inhibition alters gene expression and improves INH-mediated clearance of Mtb in rabbit lungs

ABSTRACT: Tuberculosis kills nearly 2 million people through out the world, every year. The outcome of M. tuberculosis infection is determined by the host and bacterial factors. A strong host immune response controls the growth of the bacilli effectively. However, in a host with suboptimal immune response, the bacilli grows and mounts disease. Activation of immune response following M. tuberculosis infection affects the expression of many host genes that are involved in the production of immune system molecules such as cytokines, chemokines, surface receptors and transcriptional regulators that manifest in the change of subsequent cellular events, including chemotaxis and proliferation of effector cells. The infecting bacilli counteracts the bactericidal activities of the host immune cells, prim

ORGANISM(S): Oryctolagus cuniculus

SUBMITTER: Selvakumar Subbian 

PROVIDER: E-GEOD-27992 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress