MicroRNA programs in normal and aberrant stem and progenitor cells

ABSTRACT: Emerging evidence suggests that microRNAs (miRNAs), an abundant class of ~22-nt small regulatory RNAs, play key roles in controlling the post-transcriptional genetic programs in stem and progenitor cells. Here we systematically examined miRNA expression profiles in various adult tissue-specific stem cells and their differentiated counterparts. These analyses revealed miRNA programs that are common or unique to blood, muscle, and neural stem cell populations and miRNA signatures that mark the transitions from self-renewing and quiescent stem cells to proliferative and differentiating progenitor cells. Moreover, we found a stem/progenitor transition miRNA (SPT-miRNA) signature that predicts the effects of genetic perturbations, such as loss of PTEN and the Rb family, AML-ETO expression, and

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Arnold 

PROVIDER: E-GEOD-28036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress