Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis

ABSTRACT: Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of TGFβ1 as the major player in the pathogenesis of the disease. This study designed novel human- and mouse-specific siRNAs and siRNA/DNA chimeras targeting both human and mouse common sequences and evaluated their inhibitory activity in pulmonary fibrosis induced by bleomycin and lung-specific transgenic expression of human TGFβ1. Selective novel sequences of siRNA and siRNA/DNA chimeras efficiently inhibited pulmonary fibrosis, indicating their applicability as tools for treating fibrotic disease in humans. Total RNA was extracted from lung tissue from mice with bleomycin (BLM)-induced lung fibrosis treated with mouse TGFβ1 siRNAs or vehicle on different days after BLM infusion.

ORGANISM(S): Mus musculus

SUBMITTER: Satoshi Kondo 

PROVIDER: E-GEOD-28122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Idiopathic pulmonary fibrosis is a chronic devastating disease of unknown etiology. No therapy is currently available. A growing body of evidence supports the role of transforming growth factor (TGF)-β1 as the major player in the pathogenesis of the disease. However, attempts to control its expression and to improve the outcome of pulmonary fibrosis have been disappointing. We tested the hypothesis that TGF-β1 is the dominant factor in the acute and chronic phases of pulmonary fibrosis and devel  ...[more]

Similar Datasets

Transcriptomics Development and Preclinical Efficacy of Novel Transforming Growth Factor-β1 (TGFβ1) siRNAs for Pulmonary Fibrosis
2011-11-22 | GSE28122 | GEO
Transcriptomics Ex vivo lung-organoid model for aberrant basaloid cell induction and activation
2025-11-04 | GSE249285 | GEO
Transcriptomics Tff1-expressing Tregs in lung prevents exacerbation of Bleomycin-induced pulmonary fibrosis (RNA-Seq)
2024-08-19 | GSE267864 | GEO
Transcriptomics Tff1-expressing Tregs in lung prevents exacerbation of Bleomycin-induced pulmonary fibrosis (scRNA-Seq)
2024-08-19 | GSE267863 | GEO
Genomics A master cistromic circuit governing hepatic fibrogenesis [ChIP-seq]
2013-04-29 | E-GEOD-38103 | biostudies-arrayexpress
Transcriptomics Transcriptome analysis of murine lung epithelial cells and fibroblasts derived from bleomycin-injured alveolospheres
2024-04-01 | GSE200297 | GEO
Transcriptomics Gene expression data from bleomycin-instilled lung tissue or control (Sham) of C57BL/6 mice (wild-type mice and transgenic mice expressing dominant-negative form of p38α or constitutive active form of MKK6 in type II alveolar epithelial cells).
2020-09-09 | GSE154074 | GEO
Transcriptomics SCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7
2011-04-30 | E-GEOD-21560 | biostudies-arrayexpress
Transcriptomics Single-cell RNA sequencing analysis of murine lung epithelial cells and fibroblasts derived from bleomycin-injured alveolospheres
2024-04-01 | GSE200298 | GEO
Transcriptomics PLAC8 attenuates pulmonary fibrosis and inhibits apoptosis of alveolar epithelial cells via facilitating autophagy
2024-12-17 | GSE282477 | GEO