Transcription profiling of human monocytes infected with adenovirus expressing either c-Myb or v-Myb

ABSTRACT: The transcriptional activities of c-Myb and its oncogenic variant v-Myb were compared by expressing them in primary human monocytes using recombinant adenovirus vectors. All the samples were compared to cells infected with a control adenovirus expressing only GFP. The results showed that v-Myb, which differs from c-Myb only by N- and C-terminal deletions and eleven amino acid substitutions, has a qualitatively different transcriptional activity. Experiment Overall Design: 2 replicates of each type were analyzed. Replicates were performed independently, more than a week apart.

ORGANISM(S): Homo sapiens

SUBMITTER: Scott Ness 

PROVIDER: E-GEOD-2816 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress