Deep sequencing-based expression transcriptional profiling of RAW264.7 infected with Brucella 16M

ABSTRACT: Using Solexa/Illumina's digital gene expression (DGE) system, a tag-based transcriptome sequencing method, we investigated the kinetic transcriptional profile of gene expression in macrophages infected with Brucella melitensis strain 16M. A key aspect of Brucella virulence is their ability to proliferate within professional and nonprofessional phagocytic host cells, thereby successfully bypassing the bactericidal effects of phagocytes. Their virulence and chronic infections are thought to be due to their ability to avoid the killing mechanisms within host cells. Defining the interaction between a host cell and Brucella is crucial to understanding the infectious process. Most researchers have studied the pathogens, but the host plays a very important role during infections. To date, relativ

ORGANISM(S): Mus musculus

SUBMITTER: liu qianhong 

PROVIDER: E-GEOD-28190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress