Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: benjamin vigl
PROVIDER: E-GEOD-28234 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20110519 1
Chemokines and adhesion molecules up-regulated in lymphatic endothelial cells (LECs) during tissue inflammation are thought to enhance dendritic cell (DC) migration to draining lymph nodes, but the in vivo control of this process is not well understood. We performed a transcriptional profiling analysis of LECs isolated from murine skin and found that inflammation induced by a contact hypersensitivity (CHS) response up-regulated the adhesion molecules ICAM-1 and VCAM-1 and inflammatory chemokines ...[more]