Transcription profiling of rat liver samples from animals treated with D-penicillamine and controls

ABSTRACT: Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D-penicillamine. The mechanism of this reaction is unknown, and no effective biomarkers have been identified to predict susceptibility. We postulate that cell stress caused by drugs is required to initiate the response. We used a highthroughput approach to identify factors that might represent danger signals by profiling hepatic gene expression 6 h after dosing with D-penicillamine (150 mg/kg). Our results show that the drug-treated animals cluster into two distinct groups. One group exhibits sub

ORGANISM(S): Rattus norvegicus

SUBMITTER: Paul Boutros 

PROVIDER: E-GEOD-2825 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress