Patterns and mechanisms of ancestral histone protein inheritance in budding yeast

ABSTRACT: It is widely believed that chromatin, the nucleoprotein packaging state of eukaryotic genomes, can carry epigenetic information to propagate gene expression patterns in replicating cells. However, inheritance of genomic packaging status is subject to mechanistic challenges that do not confront the inheritance of genomic DNA sequence. Most notably, histone proteins must at least transiently dissociate from the maternal genome during replication, and it is unknown whether maternal proteins re-associate with daughter genomes near the sequence they originally occupied on the maternal genome. Here, we use a novel method for tracking old proteins to measure where histone proteins accumulate after 1, 3, or 6 generations of growth in yeast. To our surprise, ancestral histones accumulate near the 5

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Assaf Weiner 

PROVIDER: E-GEOD-28269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress