Campylobacter jejuni Utilization of Mucin
Ontology highlight
ABSTRACT:
ORGANISM(S): Campylobacter jejuni
SUBMITTER: Alain Stintzi
PROVIDER: E-GEOD-28295 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
L-fucose utilization provides Campylobacter jejuni with a competitive advantage.
Stahl Martin M Friis Lorna M LM Nothaft Harald H Liu Xin X Li Jianjun J Szymanski Christine M CM Stintzi Alain A
Proceedings of the National Academy of Sciences of the United States of America 20110411 17
Campylobacter jejuni is a prevalent gastrointestinal pathogen in humans and a common commensal of poultry. When colonizing its hosts, C. jejuni comes into contact with intestinal carbohydrates, including L-fucose, released from mucin glycoproteins. Several strains of C. jejuni possess a genomic island (cj0480c-cj0490) that is up-regulated in the presence of both L-fucose and mucin and allows for the utilization of L-fucose as a substrate for growth. Strains possessing this genomic island show in ...[more]
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