Gene expression pattern of skin biopsies of epidermolysis bullosa simplex patients in comparison with control subjects

ABSTRACT: Tha altered biological pathways in Epidermolysis bulloda simplex, a rare monogenetic skin disease, have not been well characterized. Thus, the goal of this study is to characterize the expression profile of EBS patients compared with normal subjects using genomic expression analyses. Microarray analyses were performed with RNA isolated from skin biopsies. Robust multiarray analysis (RMA) normalization and Smyth’s moderated t test were used to select differentially expressed genes. Expression profiling comparisons show that 28 genes are differentially expressed in EBS patients compared to control subjects and 41 genes in EBS-DM compared to their matched controls. Nine genes involved in fatty acid metabolism and 2 genes in epidermal keratinisation are common altered expressed genes between t

ORGANISM(S): Homo sapiens

SUBMITTER: Catherine Laprise 

PROVIDER: E-GEOD-28315 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress