MicroRNA profiling in colorectal cancer highlights miR-1 involvement in MET-dependent proliferation

ABSTRACT: Abstract: Altered expression of microRNAs (miRNAs) is associated with development and progression of various human cancers by regulating the translation of oncogenes and tumor suppressor genes. In colorectal cancer (CRC), these regulators complement the Vogelstein multi-step model of pathogenesis and have the potential of becoming a novel class of tumor biomarkers and therapeutic targets. Using QRT-PCR, we measured the expression of 621 mature miRNAs in 40 CRCs and their paired normal tissues and identified 23 significantly deregulated miRNAs. We subsequently evaluated their association with clinical characteristics of the samples and presence of alterations in the molecular markers of CRC progression. Expression levels of miR-31 were correlated with CA19-9 and miR-18a, miR-21 and miR-31 w

ORGANISM(S): Homo sapiens

SUBMITTER: James Reid 

PROVIDER: E-GEOD-28364 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress