Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Tilo Kunath
PROVIDER: E-GEOD-28365 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature communications 20110823
A major barrier to research on Parkinson's disease is inaccessibility of diseased tissue for study. One solution is to derive induced pluripotent stem cells from patients and differentiate them into neurons affected by disease. Triplication of SNCA, encoding α-synuclein, causes a fully penetrant, aggressive form of Parkinson's disease with dementia. α-Synuclein dysfunction is the critical pathogenic event in Parkinson's disease, multiple system atrophy and dementia with Lewy bodies. Here we prod ...[more]