The dynamics of E1A in regulating networks and canonical pathways in quiescent cells

ABSTRACT: Adenoviruses force quiescent cells to re-enter the cell cycle to replicate their DNA, and for the most part, this is accomplished after they express the E1A protein immediately after infection. In this context, E1A is believed to inactivate cellular proteins (e.g., p130) that are known to be involved in the silencing of E2F-dependent genes that are required for cell cycle entry. However, the potential perturbation of these types of genes by E1A relative to their functions in regulatory networks and canonical pathways remains poorly understood. We have used DNA microarrays analyzed with Bayesian ANOVA for microarray (BAM) to assess changes in gene expression after E1A alone was introduced into quiescent cells from a regulated promoter. Approximately 2,401 genes were significantly modulated

ORGANISM(S): Mus musculus

SUBMITTER: Jean-Eudes Dazard 

PROVIDER: E-GEOD-28420 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress