LOXs in invasive trophoblasts

ABSTRACT: Human placental development is characterized by invasion of extravillous cytotrophoblasts (EVCTs) into the uterine wall during the first trimester of pregnancy. Peroxisome proliferator-activated receptor gamma (PPARG) plays a major role in placental development, and activation of PPARG by its agonists results in inhibition of EVCT invasion in vitro. To identify PPARG target genes, microarray analysis was performed using GeneChip technology on EVCT primary cultures obtained from first-trimester human placentas. Gene expression was compared in EVCTs treated with the PPARG agonist rosiglitazone versus control. A total of 139 differentially regulated genes were identified, and changes in the expression of the following 8 genes were confirmed by reverse transcription-quantitative polymerase cha

ORGANISM(S): Homo sapiens

SUBMITTER: Severine Degrelle 

PROVIDER: E-GEOD-28426 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress