Gene expression from mouse white, brown, and perivascular adipose tissue

ABSTRACT: Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct comparison to interscapular brown adipose tissue (BAT) has not been performed. Here we show by full genome DNA microarray analysis that global gene expression profiles of PVAT are virtually identical to BAT, with equally high expression of Ucp-1, Cidea and other genes known to be uniquely or very highly expressed in BAT. PVAT and BAT also displayed nearly identical phenotypes upon immunohistochemical analysis, and electron microscopy confirmed that PVAT contained multilocular lipid droplets and ab

ORGANISM(S): Mus musculus

SUBMITTER: Michael Czech 

PROVIDER: E-GEOD-28440 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress