Transcriptional profiling of fetal hypothalamic TRH neurons

ABSTRACT: During murine hypothalamic development, different neuroendocrine cell phenotypes are generated in overlapping periods; this suggests that cell-type specific developmental programs operate to achieve complete maturation. A balance between programs that include cell proliferation, cell cycle withdrawal as well as epigenetic regulation of gene expression characterizes neurogenesis. Thyrotropin releasing hormone (TRH) is a peptide that regulates energy homeostasis and autonomic responses. To better understand the molecular mechanisms underlying TRH neuron development, we performed a genome wide study of its transcriptome during fetal hypothalamic development. In primary cultures, TRH cells constitute 2% of the total fetal hypothalamic cell population. To purify these cells, we took advantage o

ORGANISM(S): Rattus norvegicus

SUBMITTER: Leonor Perez-Martinez 

PROVIDER: E-GEOD-28441 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress