Expression of marker genes in the lymph nodes predicts the recurrence of squamous cell vulvar carcinoma.

ABSTRACT: BACKGROUND: Regional lymph node (LN) status is a well-known prognostic factor for vulvar carcinoma (VC) patients. Although the reliable LN assessment in VC is crucial, it presents significant diagnostic problems. PURPOSE: We aimed to identify specific mRNA markers of VC dissemination in the LN and to address the feasibility of predicting the risk of nodal recurrence by the patterns of gene expression. EXPERIMENTAL DESIGN: Sentinel and inguinal LN samples from 20 patients who had undergone surgery for stage T1-3, N0-2, M0 primary vulvar squamous cell carcinoma were analyzed. Gene expression profiles were assessed in four metastatic [LN(+)] and four histologically negative [LN(-)] lymph node samples obtained from four VC patients, by the Affymetrix U133 Plus 2.0 gene expression mi

ORGANISM(S): Homo sapiens

SUBMITTER: Krzysztof Goryca 

PROVIDER: E-GEOD-28442 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress