Transcriptome of globus pallidus from a mouse having a high score of cocaine-dependent conditioned place preference

ABSTRACT: Molecular basis of transition to addiction in vulnerable individuals is largely unknown. We hypothesized that human susceptibility genes can be identified on the basis of conserved molecular mechanisms in rodent brains. We used a short-term cocaine-dependent conditioned place preference (CPP) to identify genetic hallmarks of early steps of reward memory in basal ganglia including accumbens nucleus (NAc), globus pallidus (GP) and subthalamic nucleus (STN). Using genome-wide microarray analysis and CPP as a quantitative trait, we found that synaptic plasticity-related genes are deregulated in these three structures. A significant enrichment in bona fide transcripts involved in dendritic spine local translation was evidenced. mGluR5 is transcriptionally deregulated in Acc and GP of cocaine-tr

ORGANISM(S): Mus musculus

SUBMITTER: Gilles Maussion 

PROVIDER: E-GEOD-28528 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress