Underexpression of miR-224 in methotrexate resistant human colon cancer cells

ABSTRACT: A summary of the work associated to these microarrays is the following: MicroRNAs (miRNAs) are small non-coding RNAs involved in RNA silencing that play a role in many biological processes. They are involved in the development of many diseases, including cancer. Extensive experimental data show that they play a role in the pathogenesis of cancer as well as the development of drug resistance during treatment. MiRNA microarrays of sensitive and MTX-resistant HT29 colon cancer cells were performed. The results were analyzed using the GeneSpring GX11.5 software. Differentially expressed microRNAs in resistant cells were identified and miR-224, which was greatly underexpressed and displayed robust raw signal values, was selected for further studies. Putative targets were predicted using Target

ORGANISM(S): Homo sapiens

SUBMITTER: carlos ciudad 

PROVIDER: E-GEOD-28547 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress