Identification of new genes involved in human adipogenesis and fat storage

ABSTRACT: Since the worldwide increase in obesity represents a growing challenge for the health care systems, new approaches are needed to treat obesity and associated disease effectively. The food intake is primarily stored in the adipose tissue and therefore this organ is in focus to develop new anti-obesity treatments. To provide a systematic analysis of genes that regulate adipose tissue biology and to establish a target-oriented compound screening, we performed a high throughput siRNA screen with primary (pre)adipocytes, using a druggable siRNA library targeting 7,784 human genes. Beside well known regulators of adipogenesis and neutral lipid storage (like PPAR?, RXR, Perilipin A) the screening revealed a large number of genes which were not previously described in the context of fatty tissue b

ORGANISM(S): Homo sapiens

SUBMITTER: Silvia Rueberg 

PROVIDER: E-GEOD-28628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress