Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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The YbjN regulon in Escherichia coli

ABSTRACT: YbjN, an enterobacteria-specific protein, is a multicopy suppressor of ts9 temperature sensitivity in Escherichia coli. Microarray study revealed that the expression level of ybjN was inversely correlated with the expression of flagellar, fimbrial and acid resistance genes. Over-expression of ybjN significantly down-regulated genes involved in the citric acid cycle, glycolysis, the glyoxylate shunt, oxidative phosphorylation, and amino acid and nucleotide metabolism. On the other hand, over-expression of ybjN up-regulated toxin-antitoxin modules, the SOS responsive pathway, cold shock proteins and starvation-induced transporter genes. Our results collectively suggest that YbjN may play important roles in regulating bacterial multicellular behaviors, metabolism and survival under various stress conditions in Es. coli. A total of 8 samples were analyzed: E. coli wild type strain (2 replicates); E. coli ybjN mutant strain (3 replicates); E. coli ybjN over-expression strain (3 replicates).

ORGANISM(S): Escherichia coli

SUBMITTER: Frank Zhao 

PROVIDER: E-GEOD-28630 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The orphan gene ybjN conveys pleiotropic effects on multicellular behavior and survival of Escherichia coli.

Wang Dongping D   Calla Bernarda B   Vimolmangkang Sornkanok S   Wu Xia X   Korban Schuyler S SS   Huber Steven C SC   Clough Steven J SJ   Zhao Youfu Y  

PloS one 20110927 9

YbjN, encoding an enterobacteria-specific protein, is a multicopy suppressor of temperature sensitivity in the ts9 mutant strain of Escherichia coli. In this study, we further explored the role(s) of ybjN. First, we demonstrated that the ybjN transcript was about 10-fold lower in the ts9 strain compared to that of E. coli strain BW25113 (BW). Introduction of multiple copies of ybjN in the ts9 strain resulted in over-expression of ybjN by about 10-fold as compared to that of BW. These results sug  ...[more]

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