Gene expression profiling in A2780, CP70 and CP70 following Decitabine and/or PXD101 treatment

ABSTRACT: Multiple DNA methylation changes have been associated with the acquisition of drug resistance; however it remains uncertain how many of these changes may represent critical DNA methylation drivers of chemoresistance. Using gene expression profiling method on HGU133plus2 array, we identified a total of 1370 genes showing significant gene expression changes with 687 genes going up and 683 genes going down in the resistant (cp70) versus sensitive cell lines (A2780) by Rank Product (FDR<5%). Combining expression profiling with methylation profiling data we found out of 245 hypermethylated and down-regulated genes in the resistant cell line, 41 genes were up-regulated following Decitabine treatment alone, 45 genes up-regulated following combined treatment of Decitabine and PXD101, and only 10 g

ORGANISM(S): Homo sapiens

SUBMITTER: Wei Dai 

PROVIDER: E-GEOD-28646 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress