Transcriptional Profiling of Class IV da Neurons

ABSTRACT: Elucidating the molecular mechanisms controlling dendrite development is key to understanding the pivotal role these structures play in influencing synaptic integration and neural function. Despite significant advances in this field, genetic pleiotropy remains a significant impediment to investigating such complex developmental processes. To circumvent this problem, we have applied class specific neuron transcriptional expression profiling coupled to an in vivo RNAi functional validation screen in order to dissect the molecular bases of Drosophila class IV dendritic arborization (da) neuron dendritogenesis. Microarray analyses reveal transcriptional regulation as one highly enriched biological and functional category with 420 transcription factors significantly expressed in class IV neu

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Daniel Cox 

PROVIDER: E-GEOD-28675 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress