Wild type N-ras displays anti-malignant properties, in part by downregulating decorin

ABSTRACT: Previously, we have demonstrated that wild type N-ras (wt N-ras) harbors an anti-malignant effect against mutated Ras and in tumors without Ras mutations. To investigate the molecular bases of this anti-malignant activity, we have studied the potency of this anti-malignant effect in a model system against SV40 T. We show that wild-type N-ras (wt N-ras) counteracts the effects of SV40T in NIH3T3 cells as seen by a decrease in proliferation, anchorage independence and changes in migration). We also show that wt N-ras also elicits the same anti-malignant effects in some human tumor cell lines (HT1080 and MDA-MB-231). Through mRNA and microRNA (miRNAs) expression profiling we have identified genes and miRNAs modulated by wt N-ras potentially responsible for the anti-malignant effect. wt N-ras

ORGANISM(S): Mus musculus

SUBMITTER: Jiri Zavadil 

PROVIDER: E-GEOD-28678 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress