Transcription profiling of amaygdala, cortex and hippocampus from rats subjected to immobilization stress

ABSTRACT: Prolonged stress has adverse consequences for neurons in the hippocampus (HIPP). The amygdala (AMY) is a brain region that is similar to HIPP across many measures, suggesting that chronic stress might modulate AMY and HIPP function in similar ways. However, studies addressing this issue have produced surprising results. For example, a regimen of chronic stress shown to produce atrophy in HIPP neurons caused dendritic branching in AMY neurons. These and other data have revealed that excessive stress induces fundamentally opposing processes in the AMY and HIPP, such that AMY function is facilitated by levels of stress that produce deleterious effects in HIPP. The mechanisms that contribute to the opposing responses of these brain regions to chronic stress are unknown. Such knowledge may sugg

ORGANISM(S): Rattus norvegicus

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-2870 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress