Development and Validation of a Novel Molecular Biomarker Diagnostic Test for the Early Detection of Sepsis

ABSTRACT: Introduction: Sepsis is a complex immunological response to infection characterized by early hyperinflammation followed by severe and protracted immunosuppression, suggesting that a multi-marker approach has the greatest clinical utility for early detection, within a clinical environment focused on SIRS differentiation. Pre-clinical research using an equine sepsis model identified a panel of gene expression biomarkers that define the early aberrant immune activation. Thus, the primary objective was to apply these gene expression biomarkers to distinguish patients with sepsis from those who had undergone major open surgery and had clinical outcomes consistent with systemic inflammation due to physical trauma and wound healing. Methods: This was a multi-centre, prospective clinical trial con

ORGANISM(S): Homo sapiens

SUBMITTER: Gareth Price 

PROVIDER: E-GEOD-28750 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress