Transcription profiling of rats treated with chronic doses of anti-epilepsy drugs to identify genes involved in epileptogenesis

ABSTRACT: Epilepsy is a major neurological disorder that affects approximately 1% of the population. The processes that lead to the development of epilepsy (epileptogenesis) are largely unknown. Levetiracetam is a novel antiepileptic drug (AED) that in the kindling model inhibits epileptogenesis in addition to being effective in controlling established epilepsy. The mechanisms of action of levetiracetam as an AED and an antiepileptogenic drug are unknown. By identifying the effect of chronic levetiracetam therapy on gene expression in the brain we hope to be able to identify genes that are involved in epileptogenesis. By comparing the gene expression profiles of levetiracetam and phenytoin treatments, we hope to be able to distinguish between genes that are important for the antiepileptic (anti-seiz

ORGANISM(S): Rattus norvegicus

SUBMITTER: Elizabeth Salomon 

PROVIDER: E-GEOD-2880 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress