Chromosomal aberrations and aneuploidy in oral potentially malignant lesions: distinctive features for tongue.

ABSTRACT: The mucosae of the oral cavity are different at the histological level but are all exposed to common genotoxic agents. As a result of this exposure, changes in the mucosal epithelia develop giving rise to Oral Potentially Malignant Lesions (OPMLs), which with time may in turn progress to Oral Squamous Cell Carcinomas (OSCCs). Therefore, much effort should be devoted to identify features able to predict the likeliness of progression associated with an OPML. Such features may be helpful in assisting the clinician to establish both appropriate therapies and follow-up schedules. Here, we report a pilot study that compared the anatomical subsites of OPMLs development with occurrence of DNA aneuploidy and chromosomal copy number aberrations (CNAs). Multiple samples from histologically diagnosed

ORGANISM(S): Homo sapiens

SUBMITTER: PAOLA SCARUFFI 

PROVIDER: E-GEOD-28868 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress