Genetic identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue [Illumina Expression Array]

ABSTRACT: Most loci identified in genome wide association studies (GWAS) of complex traits reside in non-coding DNA and may contribute to phenotype via changes in gene regulation. The discovery of expression quantitative trait loci (?eQTLs?) can thus be used to more precisely identify modest but real disease associations and provide insights into their underlying molecular mechanisms. This is particularly true for analyses of expression in non-transformed cells from tissues relevant to the complex traits of interest. We have conducted two independent studies to identify genetic, including both SNPs and copy-number variants, and environmental determinants of human liver gene expression variation. We analyzed two sets of primary livers (primary dataset: n=220; replication dataset: n=60) using Agilent

ORGANISM(S): Homo sapiens

SUBMITTER: Greg Cooper 

PROVIDER: E-GEOD-28893 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress