Valvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently

ABSTRACT: Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial appendage tissue from valvular heart disease (VHD) patients. Right atrial appendage from patients undergoing coronary artery bypass grafting (CABG) and left atrial (LA) appendage from healthy hearts not used for transplant were used as controls. VHD induced different changes in miR expression in LA compared with right atria (RA). Fifty-two (52) miRs were altered by VHD in LA, compared with 5 in RA tissue. There was no detectable effect of chronic AF on miR expression in LA tissue, but miR expressi

ORGANISM(S): Homo sapiens

SUBMITTER: Mark Cowley 

PROVIDER: E-GEOD-28954 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress