A set of 72 differentially expressed miRNAs provide a molecular signature for pancreatic cancer

ABSTRACT: MicroRNAs (miRNAs) are short single-stranded RNA molecules that have a critical role in the regulation of gene expression. Alterations in miRNA expression levels have been observed in multiple tumor types and there is clear evidence on their active involvement in cancer development. Here, a comprehensive miRNA expression profiling in 16 pancreatic cancer cell lines and four normal pancreatic samples provided a specific molecular signature for pancreatic cancer and enabled us to identify 72 differentially expressed miRNAs with approximately half of them being up- and half downregulated in cancer cells as compared to normal samples. Of these, miR-31 was selected for further functional analyses based on its interesting M-bM-^@M-^\on-offM-bM-^@M-^] type expression profile, i.e. very low or eve

ORGANISM(S): Homo sapiens

SUBMITTER: Eeva Laurila 

PROVIDER: E-GEOD-28955 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress