Identification and control of host innate disease causing responses to dengue infection

ABSTRACT: Our hypothesis is that dengue induces different innate immune responses in patients with mild respective severe dengue. We further hypothesize that severe dengue infection is a consequence of an over reactive inflammatory response which could be inhibited in an early stage by immune suppressants. We hypothesize that the drugs used in this study induce a down regulated inflammatory response; VP-16 by triggering apoptosis and Rosiglitazone by inhibiting NFkB related cytokine production In-vitro dengue infected U937, transcriptional assessment

ORGANISM(S): Homo sapiens

SUBMITTER: Ahmad Nazri Mohamed Naim 

PROVIDER: E-GEOD-28985 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress