Pro-invasion metastasis drivers in early stage melanoma are oncogenes

ABSTRACT: Clinical and genomic evidence support the view that the metastatic potential of a primary tumor may be dictated by transforming events acquired early in the tumorigenic process. It has been proposed that the presence of such pro-metastatic events in early-stage tumors reflects their additional capability to function as oncogenes. Here, to test this ‘deterministic’ hypothesis and identify potential pro-metastasis oncogenes, we adopted a comparative oncogenomics-guided functional genetic screening strategy involving (i) global transcriptomic data from two genetically engineered mouse models of melanoma with contrasting metastatic potential, (ii) genomic and transcriptomic profiles of human primary and metastatic melanoma and (iii) an invasion screen in TERT-immortalized human melanocytes a

ORGANISM(S): Mus musculus

SUBMITTER: Yonghong Xiao 

PROVIDER: E-GEOD-29074 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress