Calcineurin/NFAT signaling inhibits myeloid hematopoiesis in mice.

ABSTRACT: Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signaling can also mediate granulocyte and DC activation, but it is unknown whether NFAT influences their development from progenitors. Here we report a novel role for calcineurin/NFAT signaling as a negative regulator of myeloid hematopoiesis. Reconstituting lethally-irradiated mice with hematopoietic stem cells expressing an NFAT-inhibitory peptide resulted in enhanced development of the myeloid compartment. Culturing bone marrow cells with Flt3-L and Cyclosporin A, which inhibits NFAT signaling, increased numbers of differentiated DC. Global gene expression analysis of untreated DC and NFAT-inhibited DC revealed differential expres

ORGANISM(S): Mus musculus

SUBMITTER: jinmiao chen 

PROVIDER: E-GEOD-29094 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress