MicroRNA profiling and prediction of recurrence/relapse-free survival in stage I lung cancer

ABSTRACT: Despite surgical treatment of stage I non-small cell lung cancer (NSCLC), one third of patients will eventually have a recurrence. Robust prognostic markers are required to better manage therapy options. MicroRNAs play important roles in human cancers. The purpose of this study is to identify miRNA expression profiles that would better predict prognosis. Small RNAs extracted from formalin-fixed and paraffin-embedded (FFPE) tumor tissues of 357 stage I NSCLC patients were profiled on the human MicroRNA expression profiling V2 panel (Illumina). The expression differences between cancer subtypes were compared by t tests. The association of miRNA expression profile with recurrence free survival (RFS) was assessed using partial Cox regression models. Two miRNA signatures that are highly predic

ORGANISM(S): Homo sapiens

SUBMITTER: Yan Lu 

PROVIDER: E-GEOD-29135 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress