Identification of active microRNA/transcription factor feed-forward loops during human adipogenesis (miRNA)

ABSTRACT: Post-transcriptional regulation of gene expression accomplished by microRNAs (miRNAs) importantly affects the complex gene regulatory network. In particular, miRNAs are known to be involved in recurrent motifs named miRNA-mediated feed forward loops (FFLs) where a transcription factor (TF) regulates a miRNA and they both regulate the expression level of a target RNA. Here, we focus on the identification of active FFLs during adipogenic differentiation. A list of putative feed-forward loops was generated based on sequence analysis of conserved and overrepresented motifs in the regulatory regions. Since this approach is not specific for adipogenesis and is known to generate false positive feed-forward loops, an experiment was designed to select active ones based on their dynamics using a mod

ORGANISM(S): Homo sapiens

SUBMITTER: Federica Eduati 

PROVIDER: E-GEOD-29185 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress