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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide analysis of microRNA expression in Non-small Cell Lung Cancer

ABSTRACT: Analysis of NSCLC development at microRNA expression level. Results shows that has-miR-96 is significant up-regulated in the cancer tissue compared with the adjacent normal tissue. Illumina Human v2 MicroRNA expression beadchip Total microRNA obtained from 6 paired NSCLC cancer tissue and the adjacent normal tissue.

ORGANISM(S): Homo sapiens

SUBMITTER: lina ma

PROVIDER: E-GEOD-29248 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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An integrated analysis of miRNA and mRNA expressions in non-small cell lung cancers.

Ma Lina L Huang Yanyan Y Zhu Wangyu W Zhou Shiquan S Zhou Jihang J Zeng Fang F Liu Xiaoguang X Zhang Yongkui Y Yu Jun J

PloS one 20111027 10

Using DNA microarrays, we generated both mRNA and miRNA expression data from 6 non-small cell lung cancer (NSCLC) tissues and their matching normal control from adjacent tissues to identify potential miRNA markers for diagnostics. We demonstrated that hsa-miR-96 is significantly and consistently up-regulated in all 6 NSCLCs. We validated this result in an independent set of 35 paired tumors and their adjacent normal tissues, as well as their sera that are collected before surgical resection or c ...[more]

PMID: 22046296

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