LPS hypersensitivity of gp130 mutant mice is independent of elevated hematopoietic TLR4 signaling

ABSTRACT: The inflammatory mediator IL6 induced by LPS, which signals via TLR4, has been shown to feedback and augment TLR4 signaling when over-produced in LPS hypersensitive gp130F/F mice. The identity of the LPS/TLR4 responsive inflammatory signaling pathways and gene networks which are modulated by IL6 are unknown. Therefore, to understand the molecular consequences of gp130 hyperactivity in non-haemopoietic tissue on LPS-induced systemic inflammation, global gene expression profiling of livers was performed. The mouse 22K compugen oligo array from the Adelaide Microarray Facility was used to investigate the effect of LPS treatment on the livers of wildtype and gp130F/F mutant mice. Livers of both wildtype mice and gp130F/F mice at 6hr post LPS injection and also control livers wer collected.

ORGANISM(S): Mus musculus

SUBMITTER: Jodee Gould 

PROVIDER: E-GEOD-29311 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress