Gene expression profile of cancer cells and macrophages growing as a co-culture

ABSTRACT: Molecular mechanisms of the cancer cells-macrophages interactions growing in vitro conditions as a co-culture. The five canine mammary cancer cell lines were cultured with monocytes sorted from the canine blood for 72hrs. Then, the cancer cells and macrophages were sorted and the gene expression analysis was conducted. The control for each co-cultured cell line was the same cell line growing as a single culture, whereas the control for the macrophages growing in a co-culture conditions were macrophages growing as a single culture. Solid tumors are comprised of various cells, like cancer cells, resident stromal cells, migratory hemopoietic cells and so on. These cells regulate tumor growth and metastasis. Macrophages are probably the most important element of the interactions within the tum

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Magdalena KrM-CM-3l 

PROVIDER: E-GEOD-29339 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress