Genes and Pathways Underlying Regional and Cell Type Changes in Alzheimer's Disease

ABSTRACT: Along with the two hallmark pathologies—intracellular neurofibrillary tangles (NFTs) and extracellular amyloid plaques—transcriptional studies suggest that Alzheimer's disease (AD) results from dysfunction of many cellular pathways including synaptic transmission, cytoskeletal dynamics, and apoptosis. While these studies consistently point to the same pathways involved in AD, there is no consensus on which genes in each pathway are disease-relevant, much less on whether these genes play causative roles or are downstream effects of disease progression. To address these issues, we have performed a large-scale transcriptional analysis in brain of individuals with advanced AD and non-demented controls, focusing specifically on CA1 and the relatively less affected CA3. For comparisons betwee

ORGANISM(S): Homo sapiens

SUBMITTER: Jeremy Miller 

PROVIDER: E-GEOD-29378 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress