A New Mouse Model for Mania Shares Genetic Correlates with Human Bipolar Disorder

ABSTRACT: Bipolar disorder (BPD) is a debilitating heritable psychiatric disorder. Contemporary models for the manic pole of BPD have primarily utilized either single locus transgenics or treatment with psychostimulants. Our lab recently characterized a mouse strain, termed Madison (MSN), which naturally displays a manic phenotype, exhibiting elevated locomotor activity, increased sexual behavior, and higher forced swimming relative to control strains. Lithium chloride and olanzapine treatments attenuate this phenotype. In this study, we replicated our locomotor activity experiment, showing that MSN mice display generationally-stable mania relative to their outbred ancestral strain, hsd:ICR (ICR). We then performed a gene expression microarray experiment to compare hippocampus of MSN and ICR mi

ORGANISM(S): Mus musculus

SUBMITTER: Charles Saul 

PROVIDER: E-GEOD-29417 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress