Dataset Information
Systematic bias in high-throughput sequencing data and its correction by BEADS
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Thomas Down
PROVIDER: E-GEOD-29427 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Systematic bias in high-throughput sequencing data and its correction by BEADS.
Nucleic acids research 20110606 15
Genomic sequences obtained through high-throughput sequencing are not uniformly distributed across the genome. For example, sequencing data of total genomic DNA show significant, yet unexpected enrichments on promoters and exons. This systematic bias is a particular problem for techniques such as chromatin immunoprecipitation, where the signal for a target factor is plotted across genomic features. We have focused on data obtained from Illumina's Genome Analyser platform, where at least three fa ...[more]
