A methyl-deviator epigenotype of estrogen-receptor-positive breast carcinoma is associated with malignant biology

ABSTRACT: We broadly profiled DNA methylation in breast cancers (n=351) and benign parenchyma (n=47) for correspondence with disease phenotype using formalin-fixed paraffin-embedded (FFPE) diagnostic surgical pathology specimens. Exploratory analysis revealed a distinctive primary invasive carcinoma subclass featuring extreme global methylation deviation. Subsequently we tested the correlation between methylation remodeling pervasiveness and malignant biology. A methyl deviation index (MDI) was calculated for each lesion relative to terminal ductal-lobular unit (TDLU) baseline, and group comparisons revealed that high-grade, short-survival ER+ cancers manifest significantly higher MDI than low-grade, long-survival ER+ cancers. In contrast, ER- cancers display significantly lower MDI, revealing a str

ORGANISM(S): Homo sapiens

SUBMITTER: Jack Zhu 

PROVIDER: E-GEOD-29428 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress