Progesterone inhibits epithelial-to-mesenchymal transition in endometrial cancer: cell line data

ABSTRACT: Every year more than 42,000 women die of endometrial cancer, mainly due to recurrent or metastatic disease. The presence of tumor infiltrating lymphocytes (TILs) as well as progesterone receptor (PR) positivity has been correlated with improved prognosis. This study describes two mechanisms by which progesterone inhibits metastatic spread of endometrial cancer: by stimulating T-cell infiltration and by inhibiting epithelial-to-mesenchymal cell transition (EMT). Paraffin sections from patients with (n=9) or without (n=10) progressive endometrial cancer (recurrent or metastatic disease) were assessed for the presence of CD4+ (helper), CD8+ (cytotoxic) and Foxp3+ (regulatory) T-lymphocytes and PR expression. Progressive disease was observed to be associated with significant loss of TILs and l

ORGANISM(S): Homo sapiens

SUBMITTER: Paul van der Horst 

PROVIDER: E-GEOD-29435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress