Global gene expression response to BET inhibition in two cancer cell lines

ABSTRACT: The MYC transcription factor is a master regulator of diverse cancer pathways and somatic cell reprogramming. MYC is a compelling therapeutic target that exhibits cancer-specific cellular effects. Pharmacologic inhibition of MYC function has proven challenging due to its numerous modes of forced expression and the difficulty of disrupting protein-DNA interactions. Here we demonstrate the rapid and potent abrogation of MYC gene transcription by representative small molecule bromodomain inhibitors of the BET family of chromatin adaptors. This transcriptional suppression of MYC was observed in the context of the natural, chromosomally translocated, and amplified gene locus. Inhibition of BET bromodomain-promoter interactions and subsequent reduction of MYC transcript and protein levels result

ORGANISM(S): Homo sapiens

SUBMITTER: Barbara Bryant 

PROVIDER: E-GEOD-29449 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress