Effect of Advanced Paternal Age on Copy Number Variation in Offspring (custom array)

ABSTRACT: The offspring of older fathers have an increased risk of neurodevelopmental disorders such as schizophrenia and autism. It has been proposed that de novo point mutations and copy number variants (CNVs) in the continually dividing spermatogonia underlie this association. In light of the evidence implicating CNVs with schizophrenia and autism, here we use a mouse model to test the hypothesis that the offspring of older males have an increased risk of de novo CNVs. Three-month-old and fourteen- to sixteen-month-old C57BL/6J sires were mated with three-month-old dams to create control offspring and offspring of old sires, respectively. Applying genome-wide microarray screening technology, seven distinct CNVs were identified in a discovery set of twelve offspring and their parents. Competitive

ORGANISM(S): Mus musculus

SUBMITTER: Traute Flatscher-Bader 

PROVIDER: E-GEOD-29454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress