Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Epigenetic analysis of gastric cancer cell lines

ABSTRACT: Genome wide DNA methylation profiling of gastric cancer cell lines. The Illumina Goldengate DNA methylation Beadchip was used to obtain DNA methylation profiles across 1,505 CpG CpGs in 20 gastric cancer cell lines. Bisulphite converted DNA from the 20 gastric cancer cell lines were hybridised to the Illumina Goldengate Methylation Beadchip

ORGANISM(S): Homo sapiens

SUBMITTER: Tatiana Ivanova 

PROVIDER: E-GEOD-29499 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

<h4>Objective</h4>Cisplatin is a widely used gastric cancer (GC) chemotherapy; however, genetic factors regulating GC responses to cisplatin remain obscure. Identifying genes regulating cisplatin resistance could aid clinicians in tailoring treatments, by distinguishing cisplatin sensitive patients from those who might benefit from alternative platinum therapies, and highlight novel targeted strategies for overcoming cisplatin resistance. Here integrated epigenomics is applied to identify genes  ...[more]

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