The transcriptional program controlled by Runx1 during early hematopoietic development (ChIP-seq data)

ABSTRACT: Transcription factors have long been recognised as powerful regulators of mammalian development, yet it is largely unknown how individual key regulators operate within wider regulatory networks. Here we have used a combination of global gene expression and chromatin-immunoprecipitation approaches across four ES-cell-derived populations of increasing haematopoietic potential to define the transcriptional programme controlled by Runx1, an essential regulator of blood cell specification. Integrated analysis of these complementary genome-wide datasets allowed us to construct a global regulatory network model, which suggested that core regulatory circuits are activated sequentially during blood specification, but will ultimately collaborate to control many haematopoietically expressed genes.

ORGANISM(S): Mus musculus

SUBMITTER: Anagha Joshi 

PROVIDER: E-GEOD-29514 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress